What should a cyclosporine level be?

Based on the monitor results, we now can define the ideal therapeutic range of cyclosporine in whole blood as follows: 500-600 ng/ml in the first week of post-transplantation, 600-800 ng/ml in the second week to sixth month of post-transplantation, 400-600 ng/ml in the seventh to twelfth month of post-transplantation …

When should cyclosporine levels be taken?

For cyclosporine or tacrolimus trough-level monitoring, blood should be drawn 12 h after the last dose (i.e., immediately before the next dose).

What is a therapeutic tacrolimus level?

The general therapeutic range for tacrolimus is 5-20 ng/mL.

What happens when cyclosporine level is high?

For people with kidney and liver disorders: Cyclosporine may cause kidney and liver disease. If you already have kidney or liver problems, high doses of cyclosporine may make it worse. For people with serious infections: Cyclosporine may increase your risk of serious viral infections, such as polyomavirus infection.

What can affect tacrolimus levels?

The pharmacokinetics of tacrolimus are influenced by many factors, including genetic variability, acute infections, liver dysfunction, and interacting medications, which can result in elevated concentrations.

What is the drug cyclosporine used for organ transplant patients?

Cyclosporine is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is usually taken along with other medications to allow your new organ to function normally. Cyclosporine belongs to a class of drugs known as immunosuppressants.

When to draw cyclosporine trough?

A trough level is the lowest concentration reached by a drug before the next dose is administered. For example, if cyclosporine is given twice a day, a blood sample is usually drawn 12 hours after the last dose, before a new dose is given.

What is cyclosporine prescribed for?

Cyclosporine is the generic name of the prescription eye drop Restasis, used to treat dry eyes caused by an inability to produce enough natural tear fluid.