What does AAA ATPase do?

ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that perform a large variety of functions essential to cell physiology, including control of protein homeostasis, DNA replication, recombination, chromatin remodeling, ribosomal RNA processing, molecular targeting, organelle …

What binds to AAA?

Structure. The AAA domain contains two subdomains, an N-terminal alpha/beta domain that binds and hydrolyzes nucleotides (a Rossmann fold) and a C-terminal alpha-helical domain.

What are AAA+ domains?

Members of the AAA+ superfamily contain a highly conserved ATPase module of 200-250 amino acids, which includes an αβα core domain where the Walker A and B motifs of the P-loop NTPases are found [2-4].

What is the protein for AAA?

Cdc48, also called p97, VCP, CDC-48, and TER94, is a highly conserved AAA protein located mainly in the cytosol (Dargemont and Ossareh-Nazari, 2012; Yamanaka et al., 2012). Cdc48 is one of the most abundant intracellular proteins and essential for cell viability (Dalal and Hanson, 2001).

What is an Atpase domain?

They are found in all living organisms and share the common feature of the presence of a highly conserved AAA domain called the AAA module. This domain is responsible for ATP binding and hydrolysis. It contains 200-250 residues, among them there are two classical motifs, Walker A (GX4GKT) and Walker B (HyDE)

Is it Triple A or AAA?

In the video-game industry, AAA (pronounced and sometimes written Triple-A) is an informal classification used to categorise games produced and distributed by a mid-sized or major publisher, which typically have higher development and marketing budgets than other tiers of games.

What type of protein is ATPase?

1.1 Overall Architecture. The P-type ATPases are a large family of integral membrane proteins that use the energy of ATP hydrolysis to transport cations and lipids across membranes (Bublitz, Morth, & Nissen, 2011; Palmgren & Nissen, 2011).